Development and Validation of Single-Optimization Knowledge-Based Volumetric Modulated Arc Therapy Model Plan in Nasopharyngeal Carcinomas.

ABSTRACT:

Purpose

Knowledge-based planning (KBP) has evolved to standardize and expedite the complex process of radiation therapy planning for nasopharyngeal cancer (NPC). Herein, we aim to develop and validate the suitability of a single-optimization KBP for NPC.

Methods and materials

Volumetric modulated arc therapy plans of 103 patients with NPC treated between 2016 and 2020 were reviewed and used to generate a KBP model. A validation set of 15 patients was employed to compare the quality of single optimization KBP and clinical plans using the paired t test and the Wilcoxon signed rank test. The time required for either planning was also analyzed.

Results

Most patients (86.7%) were of locally advanced stage (III/IV). The median dose received by 95% of the high-risk pl

SUBMITTER: Sinha S 

PROVIDER: S-EPMC10801663 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature