Assessment of potential risk factors associated with gestational diabetes mellitus: evidence from a Mendelian randomization study.

ABSTRACT:

Background

Previous research on the association between risk factors and gestational diabetes mellitus (GDM) primarily comprises observational studies with inconclusive results. The objective of this study is to investigate the causal relationship between 108 traits and GDM by employing a two-sample Mendelian randomization (MR) analysis to identify potential risk factors of GDM.

Methods

We conducted MR analyses to explore the relationships between traits and GDM. The genome-wide association studies (GWAS) for traits were primarily based on data from the UK Biobank (UKBB), while the GWAS for GDM utilized data from FinnGen. We employed a false discovery rate (FDR) of 5% to account for multiple comparisons.

Results

The inverse-variance weighted (IVW) method indicated tha

SUBMITTER: Fu Q 

PROVIDER: S-EPMC10801737 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature