Tuning DNA Dissociation from Spherical Nucleic Acids for Enhanced Immunostimulation.

ABSTRACT: The stability of the core can significantly impact the therapeutic effectiveness of liposome-based drugs. While the spherical nucleic acid (SNA) architecture has elevated liposomal stability to increase therapeutic efficacy, the chemistry used to anchor the DNA to the liposome core is an underexplored design parameter with a potentially widespread biological impact. Herein, we explore the impact of SNA anchoring chemistry on immunotherapeutic function by systematically studying the importance of hydrophobic dodecane anchoring groups in attaching DNA strands to the liposome core. By deliberately modulating the size of the oligomer that defines the anchor, a library of structures has been established. These structures, combined with in vitro and in vivo immune stimulation analy

SUBMITTER: Dittmar JW 

PROVIDER: S-EPMC10801821 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature