Integrating network pharmacology and animal experimental validation to investigate the action mechanism of oleanolic acid in obesity.

ABSTRACT:

Background

Obesity, a condition associated with the development of widespread cardiovascular disease, metabolic disorders, and other health complications, has emerged as a significant global health issue. Oleanolic acid (OA), a pentacyclic triterpenoid compound that is widely distributed in various natural plants, has demonstrated potential anti-inflammatory and anti-atherosclerotic properties. However, the mechanism by which OA fights obesity has not been well studied.

Method

Network pharmacology was utilized to search for potential targets and pathways of OA against obesity. Molecular docking and molecular dynamics simulations were utilized to validate the interaction of OA with core targets, and an animal model of obesity induced by high-fat eating was then employed to co

SUBMITTER: Liu T 

PROVIDER: S-EPMC10802007 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature