Pseudogenomic insights into the evolution of Mycobacterium ulcerans.

ABSTRACT:

Background

Buruli ulcer (BU) disease, caused by Mycobacterium ulcerans (MU), and characterized by necrotic ulcers is still a health problem in Africa and Australia. The genome of the bacterium has several pseudogenes due to recent evolutionary events and environmental pressures. Pseudogenes are genetic elements regarded as nonessential in bacteria, however, they are less studied due to limited available tools to provide understanding of their evolution and roles in MU pathogenicity.

Results

This study developed a bioinformatic pipeline to profile the pseudogenomes of sequenced MU clinical isolates from different countries. One hundred and seventy-two MU genomes analyzed revealed that pseudogenomes of African strains corresponded to the two African lineages 1 and 2. Pseudogen

SUBMITTER: Kyei-Baffour ES 

PROVIDER: S-EPMC10802024 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature