High lipoprotein(a) concentration is associated with moyamoya disease.

ABSTRACT:

Background

Moyamoya disease (MMD) has attracted the attention of scholars because of its rarity and unknown etiology.

Methods

Data for this study were sourced from the Second Affiliated Hospital of Nanchang University. Regression analyses were conducted to examine the association in Lipoprotein [Lp(a)] and MMD. R and IBM SPSS were conducted.

Results

A cohort comprising 1012 MMD patients and 2024 controls was established through the propensity score matching method. Compared with controls, MMD patients showed higher median Lp(a) concentrations [18.5 (9.6-37.8) mg/dL vs. 14.9 (7.8-30.5) mg/dL, P < 0.001]. The odds ratios and 95% confidence intervals for Lp(a) were calculated in three models: unadjusted model, model 1 (adjusted for body mass index and systolic blood pres

SUBMITTER: Chen X 

PROVIDER: S-EPMC10802057 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature