Anti-infection effects of heparin on SARS-CoV-2 in a diabetic mouse model.

ABSTRACT: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can result in more severe syndromes and poorer outcomes in patients with diabetes and obesity. However, the precise mechanisms responsible for the combined impact of corona virus disease 2019 (COVID-19) and diabetes have not yet been elucidated, and effective treatment options for SARS-CoV-2-infected diabetic patients remain limited. To investigate the disease pathogenesis, K18-hACE2 transgenic (hACE2 ^Tg) mice with a leptin receptor deficiency (hACE2-Lepr ^-/-) or high-fat diet (hACE2-HFD) background were generated. The two mouse models were intranasally infected with a 5×10 ⁵ median tissue culture infectious dose (TCID ₅₀) of SARS-CoV-2, with serum and lung tissue samples coll

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC10802103 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature