In canine bacterial pneumonia circulating granulocyte counts determine outcome from donor cells.

ABSTRACT:

Background

In experimental canine septic shock, depressed circulating granulocyte counts were associated with a poor outcome and increasing counts with prophylactic granulocyte colony-stimulating factor (G-CSF) improved outcome. Therapeutic G-CSF, in contrast, did not improve circulating counts or outcome, and therefore investigation was undertaken to determine whether transfusing granulocytes therapeutically would improve outcome.

Study design and methods

Twenty-eight purpose-bred beagles underwent an intrabronchial Staphylococcus aureus challenge and 4 hours later were randomly assigned to granulocyte (40-100 × 10⁹ cells) or plasma transfusion.

Results

Granulocyte transfusion significantly expanded the low circulating counts for hours compared to septic c

SUBMITTER: Applefeld WN 

PROVIDER: S-EPMC10802110 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature