Antibiotic- and Fluid-Focused Bundles Potentially Improve Sepsis Management, but High-Quality Evidence Is Lacking for the Specificity Required in the Centers for Medicare and Medicaid Service's Sepsis Bundle (SEP-1).

ABSTRACT:

Objective

To address three controversial components in the Centers for Medicare and Medicaid Service's sepsis bundle for performance measure (SEP-1): antibiotics within 3 hours, a 30 mL/kg fluid infusion for all hypotensive patients, and repeat lactate measurements within 6 hours if initially elevated. We hypothesized that antibiotic- and fluid-focused bundles like SEP-1 would probably show benefit, but evidence supporting specific antibiotic timing, fluid dosing, or serial lactate requirements would not be concordant. Therefore, we performed a meta-analysis of studies of sepsis bundles like SEP-1.

Data sources

PubMed, Embase, ClinicalTrials.gov through March 15, 2018.

Study selection

Studies comparing survival in septic adults receiving versus not receiving antibioti

SUBMITTER: Pepper DJ 

PROVIDER: S-EPMC10802116 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature