Long-term opioid therapy trajectories and overdose in patients with and without cancer.

ABSTRACT:

Objective

Pain is experienced by most patients with cancer and opioids are a cornerstone of management. Our objectives were (1) to identify patterns or trajectories of long-term opioid therapy (LTOT) and their correlates among patients with and without cancer and (2) to assess the association between trajectories and risk for opioid overdose, considering the potential moderating role of cancer.

Methods and analysis

We conducted a retrospective cohort study among individuals in the US Veterans Health Administration (VHA) database with incident LTOT with and without cancer (N=44,351; N=285,772, respectively) between 2010-2017. We investigated the relationship between LTOT trajectory and all International Classification of Diseases-9 and 10-defined accidental and intentional op

SUBMITTER: Merlin JS 

PROVIDER: S-EPMC10802123 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature