Gene signatures associated with prognosis and chemotherapy resistance in glioblastoma treated with temozolomide.

ABSTRACT: Background: Glioblastoma (GBM) prognosis remains extremely poor despite standard treatment that includes temozolomide (TMZ) chemotherapy. To discover new GBM drug targets and biomarkers, genes signatures associated with survival and TMZ resistance in GBM patients treated with TMZ were identified. Methods: GBM cases in The Cancer Genome Atlas who received TMZ (n = 221) were stratified into subgroups that differed by median overall survival (mOS) using network-based stratification to cluster patients whose somatic mutations affected genes in similar modules of a gene interaction network. Gene signatures formed from differentially mutated genes in the subgroup with the longest mOS were used to confirm their association with survival and TMZ resistance in independent datas

SUBMITTER: Carter T 

PROVIDER: S-EPMC10802164 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature