New Insights into Roles of IL-7R Gene as a Therapeutic Target Following Intracerebral Hemorrhage.

ABSTRACT:

Background

Spontaneous intracerebral hemorrhage (ICH) is a subtype of stroke leading to high rates of morbidity and mortality in adults. Recent studies showed that immune and inflammatory responses might play essential roles in secondary brain injury. The purpose of this article was to provide a reference for further therapeutic strategies for ICH patients.

Methods

GSE206971 and GSE216607 datasets from the gene expression omnibus (GEO) database were used to screen the highly immune-related differentally expressed genes (IRDEGs). We used the CIBERSORT algorithm to assess the level of immune signatures infiltration and got the possible function of IRDEGs which was analyzed through Gene Ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis.

SUBMITTER: Cui J 

PROVIDER: S-EPMC10802176 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature