M⁵ C regulator-mediated methylation modification patterns and tumor microenvironment infiltration characteristics in acute myeloid leukemia.

ABSTRACT:

Background

Recently, many studies have been conducted to examine immune response modification at epigenetic level, but the candidate effect of RNA 5-methylcytosine (m⁵ C) modification on tumor microenvironment (TME) of acute myeloid leukemia (AML) is still unknown at present.

Methods

We assessed the patterns of m⁵ C modification among 417 AML cases by using nine m⁵ C regulators. Thereafter, we associated those identified modification patterns with TME cell infiltration features. Additionally, stepwise regression and LASSO Cox regression analyses were conducted for quantifying patterns of m⁵ C modification among AML cases to establish the m⁵ C-score. Meanwhile, we validated the expression of genes in the m5C-score model b

SUBMITTER: Wen Q 

PROVIDER: S-EPMC10802208 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature