Development of a PROTAC Targeting Chk1.
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ABSTRACT:
SUBMITTER: Chowdhury SR
PROVIDER: S-EPMC10802242 | biostudies-literature | 2024 Jan
REPOSITORIES: biostudies-literature
Publications
Development of a PROTAC Targeting Chk1.
Chowdhury Sandipan Roy SR Chuong Patrick P Mgbemena Victoria E VE Statsyuk Alexander A
bioRxiv : the preprint server for biology 20240101
A series of Chk1 degraders were designed and synthesized. The degraders were developed through the conjugation of a promiscuous kinase binder and thalidomide. One of the degraders PROTAC-2 was able to decrease Chk1 levels in a concentration-dependent manner in A375 cells. The developed probes can be useful for the development of selective and more potent Chk1 degraders. ...[more]
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