Development of a PROTAC Targeting Chk1.

ABSTRACT: A series of Chk1 degraders were designed and synthesized. The degraders were developed through the conjugation of a promiscuous kinase binder and thalidomide. One of the degraders PROTAC-2 was able to decrease Chk1 levels in a concentration-dependent manner in A375 cells. The developed probes can be useful for the development of selective and more potent Chk1 degraders.

SUBMITTER: Chowdhury SR 

PROVIDER: S-EPMC10802242 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature