Comment on 'Accumbens cholinergic interneurons dynamically promote dopamine release and enable motivation'.

ABSTRACT: Acetylcholine is widely believed to modulate the release of dopamine in the striatum of mammals. Experiments in brain slices clearly show that synchronous activation of striatal cholinergic interneurons is sufficient to drive dopamine release via axo-axonal stimulation of nicotinic acetylcholine receptors. However, evidence for this mechanism in vivo has been less forthcoming. A recent paper in eLife (Mohebi et al., 2023) reported that, in awake behaving rats, optogenetic activation of striatal cholinergic interneurons with blue light readily evokes dopamine release measured with the red fluorescent sensor RdLight1. Here, we show that blue light alone alters the fluorescent properties of RdLight1 in a manner that may be misconstrued as phasic dopamine release, and that

SUBMITTER: Taniguchi J 

PROVIDER: S-EPMC10802245 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature