Effects of long-term high dose aspartame on body mass, bone strength, femoral geometry, and microbiota composition in a young and aged cohort of male and female mice.

ABSTRACT:

Background

Recent reassessment of the safety of aspartame has prompted increased evaluation of its effect on the health of a range of tissues. The gut microbiome is altered by oral aspartame. One prior study suggested that changes in the microbiome caused by aspartame could influence the strength of bone in young skeletally developing mice. Here we ask how aspartame influences bone in mice of different age and sex.

Objective

The objective of this study was to determine the effect of aspartame on the bone strength and gut microbiota of young and aged mice.

Methods

Male and female C57Bl/6J mice were untreated or treated with a high dose of aspartame in their drinking water from 1 month of age until 4 (young cohort; n = 80) or 22 months (aged cohort; n = 52).

Results<

SUBMITTER: Cyphert EL 

PROVIDER: S-EPMC10802297 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature