Fas2^EB112: A Tale of Two Chromosomes.

ABSTRACT: The cell-cell adhesion molecule Fasciclin II (Fas2) has long been studied for its evolutionarily-conserved role in axon guidance. It is also expressed in the follicular epithelium, where together with a similar protein, Neuroglian (Nrg), it helps to drive the reintegration of cells born out of the tissue plane. Remarkably, one Fas2 protein null allele, Fas2^G0336, demonstrates a mild reintegration phenotype, whereas work with the classic null allele Fas2^EB112 showed more severe epithelial disorganization. These observations raise the question of which allele (if either) causes a bona fide loss of Fas2 protein function. The problem is not only relevant to reintegration but fundamentally important to understanding what this protein does

SUBMITTER: Finegan TM 

PROVIDER: S-EPMC10802346 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature