Small Intestinal Goblet Cells Control Humoral Immune Responses and Mobilization During Enteric Infection.

ABSTRACT: Humoral immune responses within the gut play diverse roles including pathogen clearance during enteric infections, maintaining tolerance, and facilitating the assemblage and stability of the gut microbiota. How these humoral immune responses are initiated and contribute to these processes are well studied. However, the signals promoting the expansion of these responses and their rapid mobilization to the gut mucosa are less well understood. Intestinal goblet cells form goblet cell-associated antigen passages (GAPs) to deliver luminal antigens to the underlying immune system and facilitate tolerance. GAPs are rapidly inhibited during enteric infection to prevent inflammatory responses to innocuous luminal antigens. Here we interrogate GAP inhibition as a key physiological response required

SUBMITTER: Kulkarni DH 

PROVIDER: S-EPMC10802374 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature