Agent-based modeling of nuclear chromosome ensemble identifies determinants of homolog pairing during meiosis.

ABSTRACT: During meiosis, pairing of homologous chromosomes (homologs) ensures the formation of haploid gametes from diploid precursor cells, a prerequisite for sexual reproduction. Pairing during meiotic prophase I facilitates crossover recombination and homolog segregation during the ensuing reductional cell division. Mechanisms that ensure stable homolog alignment in the presence of an excess of non-homologous chromosomes have remained elusive, but rapid chromosome movements during prophase I appear to play a role in the process. Apart from homolog attraction, provided by early intermediates of homologous recombination, dissociation of non-homologous associations also appears to contribute to homolog pairing, as suggested by the detection of stable non-homologous chromosome associations in pairin

SUBMITTER: Chriss A 

PROVIDER: S-EPMC10802385 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature