TRPV4 is expressed by enteric glia and muscularis macrophages of the colon but does not play a prominent role in colonic motility.

ABSTRACT:

Background

Mechanosensation is an important trigger of physiological processes in the gastrointestinal tract. Aberrant responses to mechanical input are associated with digestive disorders, including visceral hypersensitivity. Transient Receptor Potential Vanilloid 4 (TRPV4) is a mechanosensory ion channel with proposed roles in visceral afferent signaling, intestinal inflammation, and gut motility. While TRPV4 is a potential therapeutic target for digestive disease, current mechanistic understanding of how TRPV4 may influence gut function is limited by inconsistent reports of TRPV4 expression and distribution.

Methods

In this study we profiled functional expression of TRPV4 using Ca²⁺ imaging of wholemount preparations of the mouse, monkey, and human intestine in

SUBMITTER: Rajasekhar P 

PROVIDER: S-EPMC10802399 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature