Synergistic and independent roles for Nodal and FGF in zebrafish CPC migration and asymmetric heart morphogenesis.

ABSTRACT: Asymmetric development of the vertebrate heart is driven by a complex sequence of morphogenetic cell movements, coordinated through precise interpretation of signaling cues by the heart primordia. Here, we show that Nodal signaling functions synergistically with FGF to stimulate the migration of cardiac progenitor cells (CPCs) during cardiac jogging-the first morphological asymmetry observed in zebrafish heart development. While Nodal directs the asymmetric migration of CPCs, we find FGF signaling to be dispensable for this asymmetry, suggesting that FGF plays a permissive rather than instructive role. We further demonstrate that Nodal signaling induces asymmetries in actin cytoskeletal dynamics that correlate with the directional migration of CPCs, while FGF does not influence this actin

SUBMITTER: Gonzalez V 

PROVIDER: S-EPMC10802409 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature