Supergene evolution via gain of autoregulation.

ABSTRACT: Development requires the coordinated action of many genes across space and time, yet numerous species have evolved the ability to develop multiple discrete, alternate phenotypes^1-5. Such polymorphisms are often controlled by supergenes, sets of tightly-linked loci that function together to control development of a polymorphic phenotype^6-10. Although theories of supergene evolution are well-established, the mutations that cause functional differences between supergene alleles have been difficult to identify. The doublesex gene is a master regulator of insect sexual differentiation but has been co-opted to function as a supergene in multiple Papilio swallowtail butterflies, where divergent dsx alleles control development of discrete non-mimetic or m

SUBMITTER: VanKuren NW 

PROVIDER: S-EPMC10802445 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature