Systematic analysis of the effects of splicing on the diversity of post-translational modifications in protein isoforms using PTM-POSE.

ABSTRACT: Post-translational modifications (PTMs) and splicing are important regulatory processes for controlling protein function and activity. Despite examples of interplay between alternative splicing and cell signaling in literature, there have been few detailed analyses of the impacts of alternative splicing on PTMs, partly due to difficulties in extracting PTM information from splicing measurements. We developed a computational pipeline, PTM Projection Onto Splice Events (PTM-POSE), to identify "prospective" PTM sites in alternative isoforms and splice events recorded in databases using only the genomic coordinates of a splice event or isoform of interest. Importantly, PTM-POSE integrates various PTM-specific databases and tools to allow for deeper analysis of the individual and global impact

SUBMITTER: Crowl S 

PROVIDER: S-EPMC10802621 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature