Atrial Proteomic Profiling Reveals a Switch Towards Profibrotic Gene Expression Program in CREM-IbΔC-X Mice with Persistent Atrial Fibrillation.

ABSTRACT:

Background

Overexpression of the CREM (cAMP response element-binding modulator) isoform CREM-IbΔC-X in transgenic mice (CREM-Tg) causes the age-dependent development of spontaneous AF.

Purpose

To identify key proteome signatures and biological processes accompanying the development of persistent AF through integrated proteomics and bioinformatics analysis.

Methods

Atrial tissue samples from three CREM-Tg mice and three wild-type littermates were subjected to unbiased mass spectrometry-based quantitative proteomics, differential expression and pathway enrichment analysis, and protein-protein interaction (PPI) network analysis.

Results

A total of 98 differentially expressed proteins were identified. Gene ontology analysis revealed enrichment for biological proces

SUBMITTER: Zhao S 

PROVIDER: S-EPMC10802622 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature