Active avoidance recruits the anterior cingulate cortex regardless of social context in male and female rats.

ABSTRACT: Actively avoiding danger is necessary for survival. Most research has focused on the behavioral and neurobiological processes when individuals avoid danger alone, under solitary conditions. Therefore, little is known about how social context affects active avoidance. Using a modified version of the platform-mediated avoidance task in rats, we investigated whether the presence of a social partner attenuates conditioned freezing and enhances avoidance learning compared to avoidance learned under solitary conditions. Rats spent a similar percentage of time avoiding during the tone under both conditions; however, rats trained under social conditions exhibited greater freezing during the tone as well as lower rates of darting and food seeking compared to solitary rats. Under solitary conditions

SUBMITTER: Ruble S 

PROVIDER: S-EPMC10802695 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature