Improving cardiovascular risk prediction through machine learning modelling of irregularly repeated electronic health records.

ABSTRACT:

Aims

Existing electronic health records (EHRs) often consist of abundant but irregular longitudinal measurements of risk factors. In this study, we aim to leverage such data to improve the risk prediction of atherosclerotic cardiovascular disease (ASCVD) by applying machine learning (ML) algorithms, which can allow automatic screening of the population.

Methods and results

A total of 215 744 Chinese adults aged between 40 and 79 without a history of cardiovascular disease were included (6081 cases) from an EHR-based longitudinal cohort study. To allow interpretability of the model, the predictors of demographic characteristics, medication treatment, and repeatedly measured records of lipids, glycaemia, obesity, blood pressure, and renal function were used. The primary outcom

SUBMITTER: Li C 

PROVIDER: S-EPMC10802828 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature