Optimal treatment strategy and prognostic analysis for patients with non-metastatic pT4 colon adenocarcinoma.

ABSTRACT:

Objective

This study endeavored to explore the optimal treatment strategy and conduct a prognostic analysis for patients diagnosed with pT4M0 (pathologic stage T4) colon adenocarcinoma (COAD).

Methods and materials

A total of 8,843 patients diagnosed with pT4M0 COAD between January 2010 and December 2015 were included in this study from the Surveillance, Epidemiology, and End Results (SEER) database. These patients were randomly divided into a training set and an internal validation set using a 7:3 ratio. Variables that demonstrated statistical significance (P<0.05) in univariate COX regression analysis or held clinical significance were incorporated into the multivariate COX regression model. Subsequently, this model was utilized to formulate a nomogram. The predictive accu

SUBMITTER: Zhao X 

PROVIDER: S-EPMC10802841 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature