The effect of dopaminergic treatment on whole body kinematics explored through network theory.

ABSTRACT: Three-dimensional motion analysis represents a quantitative approach to assess spatio-temporal and kinematic changes in health and disease. However, these parameters provide only segmental information, discarding minor changes of complex whole body kinematics characterizing physiological and/or pathological conditions. We aimed to assess how levodopa intake affects the whole body, analyzing the kinematic interactions during gait in Parkinson's disease (PD) through network theory which assess the relationships between elements of a system. To this end, we analysed gait data of 23 people with PD applying network theory to the acceleration kinematic data of 21 markers placed on participants' body landmarks. We obtained a matrix of kinematic interactions (i.e., the kinectome) for each particip

SUBMITTER: Romano A 

PROVIDER: S-EPMC10803322 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature