Network pharmacology combined with experimental verification to explore the potential mechanism of naringenin in the treatment of cervical cancer.

ABSTRACT: Cervical cancer is the second leading cause of morbidity and mortality in women worldwide. Traditional treatment methods have become limited. Naringenin, a flavonoid abundant in various fruits and herbal medicines, has demonstrated anti-tumor properties among other effects. This research undertook to elucidate the mechanism of naringenin in the context of cervical cancer treatment by leveraging network pharmacology and performing experimental validation. Initial steps involved predicting potential naringenin targets and subsequently screening for overlaps between these targets and those related to cervical cancer, followed by analysis of their interrelationships. Molecular docking was subsequently utilized to verify the binding effect of the central target. Within the framework of network

SUBMITTER: Zhou J 

PROVIDER: S-EPMC10803340 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature