A flexible, thin-film microchannel electrode array device for selective subdiaphragmatic vagus nerve recording.

ABSTRACT: The vagus nerve (VN) plays an important role in regulating physiological conditions in the gastrointestinal (GI) tract by communicating via the parasympathetic pathway to the enteric nervous system (ENS). However, the lack of knowledge in the neurophysiology of the VN and GI tract limits the development of advanced treatments for autonomic dysfunctions related to the VN. To better understand the complicated underlying mechanisms of the VN-GI tract neurophysiology, it is necessary to use an advanced device enabled by microfabrication technologies. Among several candidates including intraneural probe array and extraneural cuff electrodes, microchannel electrode array devices can be used to interface with smaller numbers of nerve fibers by securing them in the separate channel structures. Pre

SUBMITTER: Lim J 

PROVIDER: S-EPMC10803373 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature