Combination of blockade of endothelin signalling and compensation of IGF1 expression protects the retina from degeneration.

ABSTRACT: Retinitis pigmentosa (RP) and macular dystrophy (MD) cause severe retinal dysfunction, affecting 1 in 4000 people worldwide. This disease is currently assumed to be intractable, because effective therapeutic methods have not been established, regardless of genetic or sporadic traits. Here, we examined a RP mouse model in which the Prominin-1 (Prom1) gene was deficient and investigated the molecular events occurring at the outset of retinal dysfunction. We extracted the Prom1-deficient retina subjected to light exposure for a short time, conducted single-cell expression profiling, and compared the gene expression with and without stimuli. We identified the cells and genes whose expression levels change directly in response to light stimuli. Among the genes altered by light stimulation, Igf1

SUBMITTER: Shigesada N 

PROVIDER: S-EPMC10803390 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature