Skin repair and immunoregulatory effects of myeloid suppressor cells from human cord blood in atopic dermatitis.

ABSTRACT:

Introduction

Previously, we achieved large-scale expansion of bone marrow-derived suppressor cells (MDSCs) derived from cluster of differentiation (CD)34⁺ cells cultured in human umbilical cord blood (hUCB) and demonstrated their immunomodulatory properties. In the present study, we assessed the therapeutic efficacy of hUCB-MDSCs in atopic dermatitis (AD).

Methods

Dermatophagoides farinae (Df)-induced NC/Nga mice (clinical score of 7) were treated with hUCB-MDSCs or a control drug. The mechanisms underlying the therapeutic effects of hUCB-MDSCs were evaluated.

Results and discussion

hUCB-MDSCs demonstrated immunosuppressive effects in both human and mouse CD4⁺ T cells. hUCB-MDSCs significantly reduced the clinical severity scores, which we

SUBMITTER: Kim CH 

PROVIDER: S-EPMC10803405 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature