Patient years lost due to cytomegalovirus serostatus mismatching in the scientific registry of transplant recipients.

ABSTRACT:

Background

The cytomegalovirus (CMV) mismatch rate in deceased donor kidney transplant (DDKT) recipients in the US remains above 40%. Since CMV mismatching is common in DDKT recipients, the cumulative effects may be significant in the context of overall patient and graft survival. Our primary objective was to describe the short- and long-term risks associated with high-risk CMV donor positive/recipient negative (D+/R-) mismatching among DDKT recipients with the explicit goal of deriving a mathematical mismatching penalty.

Methods

We conducted a retrospective, secondary analysis of the Scientific Registry of Transplant Recipients (SRTR) database using donor-matched DDKT recipient pairs (N=105,608) transplanted between 2011-2022. All-cause mortality and graft failure hazard ra

SUBMITTER: Abidi MZ 

PROVIDER: S-EPMC10803440 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature