Causal role of immune cells in generalized anxiety disorder: Mendelian randomization study.

ABSTRACT:

Background

Generalized anxiety disorder (GAD) is a prevalent emotional disorder that has received relatively little attention regarding its immunological basis. Recent years have seen the widespread use of high-density genetic markers such as SNPs or CNVs for genotyping, as well as the advancement of genome-wide association studies (GWAS) technologies, which have facilitated the understanding of immunological mechanisms underlying several major psychiatric disorders. Despite these advancements, the immunological basis of GAD remains poorly understood. In light of this, we aimed to explore the causal relationship between immune cells and the disease through a Mendelian randomization study.

Methods

The summary information for GAD (Ncase=4,666, Ncontrol=337,577) was obtained fr

SUBMITTER: Ma Z 

PROVIDER: S-EPMC10803460 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature