Characterisation of FLT3 alterations in childhood acute lymphoblastic leukaemia.

ABSTRACT:

Background

Alterations of FLT3 are among the most common driver events in acute leukaemia with important clinical implications, since it allows patient classification into prognostic groups and the possibility of personalising therapy thanks to the availability of FLT3 inhibitors. Most of the knowledge on FLT3 implications comes from the study of acute myeloid leukaemia and so far, few studies have been performed in other leukaemias.

Methods

A comprehensive genomic (DNA-seq in 267 patients) and transcriptomic (RNA-seq in 160 patients) analysis of FLT3 in 342 childhood acute lymphoblastic leukaemia (ALL) patients was performed. Mutations were functionally characterised by in vitro experiments.

Results

Point mutations (PM) and internal tandem duplications (ITD) were det

SUBMITTER: Gutierrez-Camino A 

PROVIDER: S-EPMC10803556 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature