The immune factors have complex causal regulation effects on inflammatory bowel disease.

ABSTRACT:

Background

Although a correlation between immune cell phenotypes and inflammatory bowel disease (IBD) has been established, a causal relationship remains unestablished.

Methods

To assess causal associations between immune cell phenotypes and IBD and its subtypes, we employed Mendelian randomization (MR) methods and genome-wide association studies (GWAS) summary statistics. The primary outcomes were determined based on the inverse variance weighting (IVW) results, with the assessment of heterogeneity and pleiotropy conducted through Cochrane's Q-test and MR-Egger. The stability of the MR results was then examined using leave-one-out analysis, and false discovery rate (FDR) correction was applied to evaluate the strength of the causal relationship between exposure and outcome.

SUBMITTER: Qiu B 

PROVIDER: S-EPMC10803565 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature