Deficiency of copper responsive gene stmn4 induces retinal developmental defects.

ABSTRACT: As part of the central nervous system (CNS), the retina senses light and also conducts and processes visual impulses. The damaged development of the retina not only causes visual damage, but also leads to epilepsy, dementia and other brain diseases. Recently, we have reported that copper (Cu) overload induces retinal developmental defects and down-regulates microtubule (MT) genes during zebrafish embryogenesis, but whether the down-regulation of microtubule genes mediates Cu stress induced retinal developmental defects is still unknown. In this study, we found that microtubule gene stmn4 exhibited obviously reduced expression in the retina of Cu overload embryos. Furthermore, stmn4 deficiency (stmn4^-/-) resulted in retinal defects similar to those seen in Cu overload embryos, wh

SUBMITTER: Jing Y 

PROVIDER: S-EPMC10803583 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature