Flunixin meglumine tissue residues after intravenous administration in goats.

ABSTRACT:

Background

Flunixin is commonly used in goats in an extra-label manner, indicating a significant need to determine withdrawal intervals for edible tissues.

Objective

The objectives of the present study were to investigate the depletion of flunixin meglumine in various goat tissues, including the liver, kidney, fat, and muscle.

Methods

Twenty Boer goats were enrolled and administered an intravenous dose (2.2 mg/kg) of flunixin meglumine. Five animals were randomly euthanized at 24, 48, 72, or 96 h following dosing. All samples were analyzed via ultra-performance liquid chromatography coupled with mass spectrometry.

Results

The concentration of flunixin in all tissues declined rapidly, with the highest mean concentrations quantified in the kidney (0.137 ± 0.062 μ

SUBMITTER: Giles CB 

PROVIDER: S-EPMC10803588 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature