Stem cell therapy for heart failure in the clinics: new perspectives in the era of precision medicine and artificial intelligence.

ABSTRACT: Stem/progenitor cells have been widely evaluated as a promising therapeutic option for heart failure (HF). Numerous clinical trials with stem/progenitor cell-based therapy (SCT) for HF have demonstrated encouraging results, but not without limitations or discrepancies. Recent technological advancements in multiomics, bioinformatics, precision medicine, artificial intelligence (AI), and machine learning (ML) provide new approaches and insights for stem cell research and therapeutic development. Integration of these new technologies into stem/progenitor cell therapy for HF may help address: 1) the technical challenges to obtain reliable and high-quality therapeutic precursor cells, 2) the discrepancies between preclinical and clinical studies, and 3) the personalized selection of optimal the

SUBMITTER: Chowdhury MA 

PROVIDER: S-EPMC10803627 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature