Body mass index, triglyceride-glucose index, and prostate cancer death: a mediation analysis in eight European cohorts.

ABSTRACT:

Background

Insulin resistance is a hypothesised biological mechanism linking obesity with prostate cancer (PCa) death. Data in support of this hypothesis is limited.

Methods

We included 259,884 men from eight European cohorts, with 11,760 incident PCa's and 1784 PCa deaths during follow-up. We used the triglyceride-glucose (TyG) index as indicator of insulin resistance. We analysed PCa cases with follow-up from PCa diagnosis, and the full cohort with follow-up from the baseline cancer-free state, thus incorporating both PCa incidence and death. We calculated hazard ratios (HR) and the proportion of the total effect of body mass index (BMI) on PCa death mediated through TyG index.

Results

In the PCa-case-only analysis, baseline TyG index was positively associated with

SUBMITTER: Fritz J 

PROVIDER: S-EPMC10803806 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature