Constipation preceding depression: a population-based cohort study.

ABSTRACT:

Background

Constipation is generally considered a common physical symptom of depression or a side effect of antidepressant treatments. However, according to the gut-brain axis hypothesis, the association between depression and constipation might be bi-directional. This study investigated the association between premorbid constipation and depression.

Methods

We conducted a retrospective cohort study using data from UK Biobank. Individuals free of depression between 2006 and 2010 were included. Constipation status was determined using diagnostic codes from electronic health records or a baseline questionnaire. Data on covariates, including socio-demographic characteristics, lifestyle factors, health conditions, and regular medication use, were also collected through a baseline

SUBMITTER: Yun Q 

PROVIDER: S-EPMC10803902 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature