Differences in risk factors for transmission among Shiga toxin-producing Escherichia coli serogroups and stx profiles.

ABSTRACT:

Objectives

Trends in the incidence of O157 and non-O157 serogroups of Shiga toxin-producing Escherichia coli (STEC) infections have markedly diverged. Here, we estimate the extent to which STEC serogroups share the same transmission routes and risk factors, potentially explaining these trends.

Methods

With 3048 STEC cases reported in Minnesota from 2010 to 2019, we used lasso penalized regression to estimate pooled odds ratios (pOR) for the association between STEC risk factors and specific STEC serogroups and Shiga toxin gene profiles. We used random forests as a confirmatory analysis.

Results

Across an extended period of time, we found evidence for person-to-person transmission associated with the O26 serogroup, relative to other serogroups (pOR = 1.32 for contact w

SUBMITTER: Tarr GAM 

PROVIDER: S-EPMC10803930 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature