Intra-serotypic antigenic diversity of dengue virus serotype 3 in Thailand during 2004-2015.

ABSTRACT: In addition to the well-known differences among the four dengue serotypes, intra-serotypic antigenic diversity has been proposed to play a role in viral evolution and epidemic fluctuation. A replacement of genotype II by genotype III of dengue virus serotype 3 (DENV3) occurred in Thailand during 2007-2014, raising questions about the role of intra-serotypic antigenic differences in this genotype shift. We characterized the antigenic difference of DENV3 of genotypes II and III in Thailand, utilizing a neutralizing antibody assay with DENV3 vaccine sera and monotypic DENV3 sera. Although there was significant antigenic diversity among the DENV3, it did not clearly associate with the genotype. Our data therefore do not support the role of intra-serotypic antigenic difference in the genotype r

SUBMITTER: Masrinoul P 

PROVIDER: S-EPMC10804135 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature