Advances in device-based treatment of heart failure with preserved ejection fraction: evidence from clinical trials.

ABSTRACT: Heart failure with preserved ejection fraction (HFpEF) is a group of clinical syndromes that exhibit a remarkably heterogeneous phenotype, characterized by symptoms and signs of heart failure, left ventricular diastolic dysfunction, elevated levels of natriuretic peptides, and an ejection fraction greater than or equal to 50%. With the aging of the population and the escalating prevalence of hypertension, obesity, and diabetes, the incidence of HFpEF is progressively rising. Drug therapy options for HFpEF are currently limited, and the associated high risk of cardiovascular mortality and heart failure rehospitalization significantly impact patients' quality of life and longevity while imposing a substantial economic burden on society. Recent research indicates that certain device-based the

SUBMITTER: Wu Y 

PROVIDER: S-EPMC10804156 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature