Outcome prediction by myocardial external efficiency from ¹¹ C-acetate positron emission tomography in cardiac amyloidosis.

ABSTRACT:

Aims

This study aimed to study the prognostic value of myocardial oxygen consumption (MVO₂ ) and myocardial external efficiency (MEE) from ¹¹ C-acetate positron emission tomography (PET) in cardiac amyloidosis (CA) patients.

Methods and results

Forty-eight CA patients, both transthyretin (ATTR) and immunoglobulin light chain (AL) amyloidosis, and 20 controls were included. All subjects were examined with ¹¹ C-acetate PET and echocardiography. MVO₂ , forward stroke volume (FSV), and left ventricular mass (LVM) were derived from ¹¹ C-acetate PET and used to calculate MEE. CA patients were followed for survival and the prognostic impact of clinical, echocardiographic, and ¹¹ C-acetate PET parameters was analysed.

SUBMITTER: Rosengren S 

PROVIDER: S-EPMC10804164 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature