Sex-specific cardiovascular protein levels and their link with clinical outcome in heart failure.

ABSTRACT:

Aims

This study aims to provide insight into sex-specific cardiovascular protein profiles and their associations with adverse outcomes, which may contribute to a better understanding of heart failure (HF) pathophysiology and the optimal use of circulating proteins for prognostication in women and men.

Methods and results

In 250 stable patients with HF with reduced ejection fraction (HFrEF), we performed trimonthly blood sampling (median follow-up: 26 [17-30] months). We selected all baseline samples and two samples closest to the primary endpoint (PEP; composite of cardiovascular death, heart transplantation, left ventricular assist device implantation, and HF hospitalization) or one sample closest to censoring and applied the Olink Cardiovascular III panel. We used linear r

SUBMITTER: de Bakker M 

PROVIDER: S-EPMC10804167 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature