Identification of the communal pathogenesis and immune landscape between viral myocarditis and dilated cardiomyopathy.

ABSTRACT:

Aims

Studies have confirmed that viral myocarditis (VMC) is one of the risk factors for dilated cardiomyopathy (DCM). The molecular mechanisms underlying the progression from VMC to DCM remain unclear and require further investigation.

Methods and results

The mRNA microarray datasets GSE57338 (DCM) and GSE1145 (VMC) were obtained from the Gene Expression Omnibus database. The candidate key genes were further screened using weighted correlation network analysis (WGCNA), protein-protein interaction and external dataset validation, and the correlation between the candidate key genes and immune cells and the signalling pathways of the candidate key genes were observed by enrichment analysis and immune infiltration analysis. The expression of key genes was validated in the extern

SUBMITTER: Lei Z 

PROVIDER: S-EPMC10804177 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature