Heart failure with preserved ejection fraction, red cell distribution width, and sacubitril/valsartan.

ABSTRACT:

Aims

Red cell distribution width (RDW) is a strong prognostic marker in patients with heart failure (HF) and reduced ejection fraction and other conditions. However, very little is known about its prognostic significance in HF with preserved ejection fraction. We examined the relationship between RDW and outcomes and the effect of sacubitril/valsartan, compared with valsartan, on RDW and clinical outcomes in PARAGON-HF.

Methods and results

PARAGON-HF enrolled patients with a left ventricular ejection fraction of ≥45%, structural heart disease, and elevated N-terminal pro-B-type natriuretic peptide (NT-proBNP). The primary endpoint was a composite of total HF hospitalizations and cardiovascular deaths. Median RDW at randomization was 14.1% (interquartile range 13.5-15.0%). Pa

SUBMITTER: Butt JH 

PROVIDER: S-EPMC10804200 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature