Guideline implementation, drug sequencing, and quality of care in heart failure: design and rationale of TITRATE-HF.

ABSTRACT:

Aims

Current heart failure (HF) guidelines recommend to prescribe four drug classes in patients with HF with reduced ejection fraction (HFrEF). A clear challenge exists to adequately implement guideline-directed medical therapy (GDMT) regarding the sequencing of drugs and timely reaching target dose. It is largely unknown how the paradigm shift from a serial and sequential approach for drug therapy to early parallel application of the four drug classes will be executed in daily clinical practice, as well as the reason clinicians may not adhere to new guidelines. We present the design and rationale for the real-world TITRATE-HF study, which aims to assess sequencing strategies for GDMT initiation, dose titration patterns (order and speed), intolerance for GDMT, barriers for implemen

SUBMITTER: Clephas PRD 

PROVIDER: S-EPMC10804201 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature