Association of anaemia on heart failure and left ventricular function: A bidirectional Mendelian randomization study.

ABSTRACT:

Aims

Observational studies have suggested that anaemia is associated with an increased risk of heart failure (HF). But the potential causal association is not clear. We aimed to investigate the association between anaemia and HF risk.

Methods and results

A Mendelian randomization (MR) analysis was performed to confirm the causal association of anaemia with the risk of HF and left ventricular structure and function. Furthermore, a reverse-direction MR analyses was conducted to assess the causal effect of HF on anaemia. The MR analysis indicated that genetically predicted anaemia is associated with the increased risk of HF (meta: odd ratio (OR) = 1.12; 95% confidence interval (CI) [1.04, 1.20]; P = 0.002), and left ventricular mass index (β = 1.051; 95% CI [0.384, 1.718]; P = 

SUBMITTER: Ying Y 

PROVIDER: S-EPMC10804204 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature